The dominant negative thyroid hormone receptor β mutant ∆ 337 T alters peroxisome proliferator - activated receptor α signaling in heart
نویسندگان
چکیده
Division of Cardiology, Department of Pediatrics, Children’s Hospital & Regional Medical Center, 4800 Sand Point Way N.E., Seattle, WA 98105 and University of Washington School of Medicine USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Department of Pediatrics, 1100 Bates Street, Houston, TX 77030, USA. Department of Biostatistics and Applied Mathematics, University of Texas M.D.Anderson Cancer Center, Houston, TX 77030 Center for Expression Arrays, Department of Microbiology, University of Washington, School of Medicine, Seattle, WA 98195
منابع مشابه
Thyroid hormone receptor mutants: Dominant negative regulators of peroxisome proliferator-activated receptor action
Thyroid hormone (T3) and peroxisome proliferators have overlapping metabolic effects in the maintenance of lipid homeostasis. Their actions are mediated by their respective receptors: thyroid hormone receptors (TR) and peroxisome proliferator-activated receptors (PPAR). We recently found that a dominantly negative TR mutant (PV) that causes a genetic disease, resistance to thyroid hormone, acts...
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Retinoid-like receptors play a central role in hormonal responses by forming heterodimers with other nuclear hormone receptors. In this study we have identified the peroxisome proliferator-activated receptor (PPAR) as a new thyroid hormone receptor (THR) auxiliary nuclear protein, heterodimerizing with THR in solution. Although these heterodimers do not recognize a classical thyroid hormone res...
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Peroxisome proliferator-activated receptor alpha (PPAR-α), which belongs to the nuclear receptor family of ligand-activated transcription factors, was first described as gene regulators for metabolic pathways including lipid metabolism, insulin sensitivity, and glucose homeostasis. Were raised. This nuclear receptor is widely expressed in various tissues, providing a wide range of effects to st...
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Objective(s): Herbal medicines are promising cancer preventive candidates. It has been shown that Punica granatum L. could inhibit angiogenesis and tumor invasion. In this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (PPE) is partly attributable to Peroxisome proliferator-activated receptors (PPARs) activation in the Human Umbilical Vein Endothelial Cell...
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تاریخ انتشار 2006